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Article

Analysis of Immobilized Protein Unfolding and Molecular Dynamics Shows How pH, Glycosylation, and OCA3-Related Variants Influence Tyrp1's Stability and Function.

International journal of molecular sciences - 30 May 2026

Sabir Waleed, Osuna Isabella, Dolinska Monika B, Sergeev Yuri V

Abstract excerpt

Tyrosinase-related protein 1 (Tyrp1) is a melanosomal glycoprotein required for eumelanin biosynthesis through the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA). Pathogenic variants in Tyrp1 cause oculocutaneous albinism type 3 (OCA3), but the molecular basis by which individual substitutions impair Tyrp1 stability and activity remains incompletely understood. Here, we examined wild-type Tyrp1 and...

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Identifiers

PMID: 42278487
DOI: 10.3390/ijms27114961
PMCID: PMC13256153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Analysis of Immobilized Protein Unfolding and Molecular Dynamics Shows How pH, Glycosylation, and OCA3-Related Variants Influence Tyrp1's Stability and Function.PMID 42278487Read ↗

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