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Genetic insights into the association between inflammatory bowel disease and Alzheimer's disease.

Genes and immunity - 1 Oct 2025

Zeng Lu, White Charles C, Bennett David A, Klein Hans-Ulrich, De Jager Philip L

Abstract excerpt

Myeloid cells, including monocytes, macrophages, and microglia, play major roles in innate and adaptive immune responses. Alzheimer's disease (AD) and inflammatory bowel disease (IBD) susceptibility loci are both enriched for genes expressed in myeloid cells, so we assessed whether these myeloid pathways may be shared. Leveraging genome-wide association study results, we investigated the causal effect of IBD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40670704
DOI: 10.1038/s41435-025-00344-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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