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Mendelian randomization and genetic pleiotropy analysis for the connection between inflammatory bowel disease and Alzheimer's disease.

Progress in neuro-psychopharmacology & biological psychiatry - 10 Jan 2025

Wu Yuxuan, Yan Yu, Qi Jike, Liu Yuxin, Wang Ting, Chen Hao, Guan Xinying, Zheng Chu, Zeng Ping

Abstract excerpt

BACKGROUND: The gut-microbiome-brain axis (GMBA) implies the connection between inflammatory bowel disease (IBD) and Alzheimer's disease (AD). We aimed to comprehensively explore the relation between IBD (and its subtypes) and AD, early-onset AD (EOAD) and late-onset AD (LOAD) from a genetic pleiotropy perspective. METHODS: Relying on summary statistics (N = 472,868 for AD, 185,204 for EOAD, 191,061 for LOAD,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39579960
DOI: 10.1016/j.pnpbp.2024.111203

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