Article
Emerging resistance to novel β-lactam β-lactamase inhibitor combinations in Klebsiella pneumoniae bearing KPC variants.
Journal of global antimicrobial resistance - 1 Sept 2025
Hamza Mase, Traglia German M, Maccari Lucia, Gomez Sonia, Sanz Maria Belen, Akhtar Usman, Mezcord Vyanka, Escalante Jenny, Corso Alejandra, Rodriguez Cecilia, Bethel Christopher R, Rao Gauri G, Tolmasky Marcelo E, Paterson David, Bonomo Robert A, Pasteran Fernando, Ramirez Maria Soledad
Abstract excerpt
OBJECTIVE: Klebsiella pneumoniae carbapenemase (KPC) variants, predominantly KPC-2 and KPC-3, are significant global resistance mechanisms, conferring resistance to many β-lactams, including carbapenems, while remaining susceptible to ceftazidime-avibactam (CZA). Recently, new KPC variants have developed resistance to CZA through mutations, insertions, or deletions in regions such as the Ω-loop, 240-loop (237-243...
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