Back to search

Article

Phenotypic and Molecular Characterization of a Novel blaKPC-202 Variant, Capable of Reverting to blaKPC-2 In Vitro in a Clinical Klebsiella pneumoniae Isolate

2026-08-31

Abstract excerpt

<title>Abstract</title> <p> <bold>Objective:</bold> This study characterized the mechanism of ceftazidime–avibactam (CZA) resistance and heteroresistance to meropenem (MEM) in a clinical <italic>Klebsiella pneumoniae</italic> isolate A1518. <bold>Methods:</bold> Broth microdilution was used to determine the minimum inhibitory concentrations (MICs) of isolate A1518 and its recombinant transformants. Whole-ge...

Identifiers and source

Literature Corpus work
d850ca94-6f19-5bf3-a6a5-4d84171173a1
DOI
10.21203/rs.3.rs-10472930/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Phenotypic and Molecular Characterization of a Novel blaKPC-202 Variant, Capable of Reverting to blaKPC-2 In Vitro in a Clinical Klebsiella pneumoniae IsolateDOI 10.21203/rs.3.rs-10472930/v1
Genomic and molecular characterisation of a KPC-producing Klebsiella pneumoniae clinical isolate resistant to meropenem-vaborbactam, imipenem-relebactam, and ceftazidime-avibactamSemantic proximity
Distribution of β-lactamase Gene and Genetic Context of blaKPC-2 in Clinical Carbapenemase-producing Klebsiella Pneumoniae IsolatesSemantic proximity
Identification of a Novel KPC Variant, KPC-204, Conferring Resistance to Both Carbapenems and Ceftazidime-Avibactam in an ST11 Klebsiella Pneumoniae StrainSemantic proximity
Evolution of ceftazidime-avibactam resistance driven by variation in blaKPC-2 to blaKPC-190 during treatment of ST11-K64 hypervirulent Klebsiella pneumoniaeSemantic proximity
Identification of a Novel KPC Variant, KPC-204, Conferring Resistance to Both Carbapenems and Ceftazidime–Avibactam in an ST11 Klebsiella pneumoniae StrainSemantic proximity
Emergence of a novel hybrid plasmid carrying bla NDM-5 in a Klebsiella pneumoniae isolate producing KPC-2Semantic proximity
Emerging Resistance to Novel -βLactam β-Lactamase Inhibitor Combinations in Klebsiella pneumoniae bearing KPC VariantsSemantic proximity
A large-scale surveillance revealed that KPC variants mediated ceftazidime-avibactam resistance in clinically isolated Klebsiella pneumoniae.Semantic proximity
Shifting of blaKPC-2 to blaKPC-90 in a sequence type 11 Klebsiella pneumoniae strain before the use of ceftazidime-avibactam.Semantic proximity
Emergence of ceftazidime-avibactam resistance due to a novel blaKPC-2 mutation during treatment of carbapenem-resistant Klebsiella pneumoniae infections.Semantic proximity
Evolution of ceftazidime-avibactam resistance driven by mutations in double-copy blaKPC-2 to blaKPC-189 during treatment of ST11 carbapenem-resistant Klebsiella pneumoniae.Semantic proximity
Emergence of KPC-134, a KPC-2 variant associated with ceftazidime-avibactam resistance in a ST11 Klebsiella pneumoniae clinical strainSemantic proximity
Select a neighboring publication to make it the new centre.