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Klebsiella pneumoniae carbapenemase variants: the new threat to global public health

8 Nov 2023

Abstract excerpt

SUMMARY Klebsiella pneumoniae carbapenemase (KPC) variants, which refer to the substitution, insertion, or deletion of amino acid sequence compared to wild bla KPC type, have reduced utility of ceftazidime-avibactam (CZA), a pioneer antimicrobial agent in treating carbapenem-resistant Enterobacterales infections. So far, more than 150 bla KPC variants have been reported worldwide, and most of the new variants...

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PMID: 37937997
DOI: 10.1128/cmr.00008-23

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