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Immunologic risk stratification of pediatric heart transplant patients by combining HLA-EMMA and PIRCHE-II

14 Mar 2023

Abstract excerpt

Human leukocyte antigen (HLA) molecular mismatch is a powerful biomarker of rejection. Few studies have explored its use in assessing rejection risk in heart transplant recipients. We tested the hypothesis that a combination of HLA Epitope Mismatch Algorithm (HLA-EMMA) and Predicted Indirectly Recognizable HLA Epitopes (PIRCHE-II) algorithms can improve risk stratification of pediatric heart transplant...

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PMID: 36999035
DOI: 10.3389/fimmu.2023.1110292

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