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Article

Linking genetic and phenotypic bedaquiline resistance in Mycobacterium tuberculosis strains from Georgia.

PloS one - 1 Jan 2025

Maghradze Nino, Loiseau Chloé, Goig Galo Adrian, Bablishvili Nino, Jugheli Levan, Borrell Sonia, Tukvadze Nestani, Kempker Russell Ryan, Avaliani Zaza, Gagneux Sebastien

Abstract excerpt

INTRODUCTION: Resistance to bedaquiline - a novel, promising medication against tuberculosis (TB), is already emerging, and uncertainties regarding the role of the different resistance-conferring mutations complicate the development of molecular diagnostic tools for detecting resistance. Mutations in the three genes atpE, pepQ, and Rv0678 have been associated with increased minimum inhibitory concentrations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40663566
DOI: 10.1371/journal.pone.0326794
PMCID: PMC12262877

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