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Article

Elevated tumor NOS2/COX2 promotes immunosuppressive phenotypes associated with poor survival in ER- breast cancer.

JCI insight - 22 Aug 2025

Ridnour Lisa A, Cheng Robert Ys, Heinz William F, Pore Milind, Gonzalez Ana L, Femino Elise L, Moffat Rebecca L, Wink Adelaide L, Imtiaz Fatima, Coutinho Leandro L, Butcher Donna, Edmondson Elijah F, Rangel M Cristina, Wong Stephen Tc, Lipkowitz Stanley, Glynn Sharon A, Vitek Michael P, McVicar Daniel W, Li Xiaoxian, Anderson Stephen K, Paolocci Nazareno, Hewitt Stephen M, Ambs Stefan, Billiar Timothy R, Chang Jenny C, Lockett Stephen J, Wink David A

Abstract excerpt

Tumor immunosuppression affects survival and treatment efficacy. Tumor NOS2/COX2 coexpression strongly predicts poor outcome in estrogen receptor-negative (ER-) breast cancer by promoting metastasis, drug resistance, cancer stemness, and immune suppression. Herein, a spatially distinct NOS2/COX2 and CD3+CD8+PD1- T effector (TEff) cell landscape correlated with poor survival in ER- tumors. NOS2 was primarily...

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Source

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Identifiers

PMID: 40663402
DOI: 10.1172/jci.insight.193091
PMCID: PMC12406732

Genes

NOS2
CD4
IDO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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Elevated tumor NOS2/COX2 promotes immunosuppressive phenotypes associated with poor survival in ER- breast cancer.PMID 40663402Read ↗

Spatial analysis of NOS2 and COX2 interaction with T-effector cells reveals immunosuppressive landscapes associated with poor outcome in ER- breast cancer patientsSemantic proximity Read ↗

NOS2 and COX2 Provide Key Spatial Targets that Determine Outcome in ER-Breast CancerSemantic proximity Read ↗

Interferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcomeSemantic proximity Read ↗

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