Article
S-nitrosylated COX-2 is a microenvironment-regulated breast cancer cell biomarker of mesenchymal phenotypes.
Experimental cell research - 1 Mar 2026
Hoffmann Reuben J, Bensen AeSoon, Dane Mark, Arterberry Jane, Smith Rebecca, Korkola James, Schedin Pepper
Abstract excerpt
COX-2, an inducible enzyme key to production of inflammatory prostaglandins, has tumor cell-intrinsic oncogenic activity. Previously, we reported Cys-526-nitrosylated COX-2 (SNO-COX-2) associates with breast cancer progression and poor-prognostic young onset breast cancer. Here, using a 3D culture model of early-stage human breast cancer (MCF10DCIS cells), we report SNO-COX-2, but not non-nitrosylated COX-2,...
Topics
- Humans
- Cyclooxygenase 2
- Breast Neoplasms
- Female
- Tumor Microenvironment
- Epithelial-Mesenchymal Transition
- Biomarkers, Tumor
- Phenotype
- Cell Line, Tumor
- Gene Expression Regulation, Neoplastic