Article

NOS2 and COX2 Provide Key Spatial Targets that Determine Outcome in ER-Breast Cancer

2023-12-23

Abstract excerpt

Estrogen receptor-negative (ER-) breast cancer is an aggressive breast cancer subtype with limited therapeutic options. Upregulated expression of both inducible nitric oxide synthase (NOS2) and cyclo-oxygenase (COX2) in breast tumors predicts poor clinical outcomes. Signaling molecules released by these enzymes activate oncogenic pathways, driving cancer stemness, metastasis, and immune suppression. The influence...

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Literature Corpus work: 6f6d6a55-85b3-5af6-8dee-e6ea0505baf4
DOI: 10.1101/2023.12.21.572859

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