Article
Cancer-associated SPOP mutations enlarge nuclear size and facilitate nuclear envelope rupture upon farnesyltransferase inhibitor treatment.
The Journal of clinical investigation - 15 Jul 2025
Wang Zixi, Li Lei, Ye Qi, Lei Yuzeshi, Lu Mingming, Ye Leihong, Kang Jialu, Huang Wenyue, Xu Shan, Wang Ke, Liu Jing, Gao Yang, Wang Chenji, Ma Jian, Li Lei
Abstract excerpt
Nuclear size is crucial for cellular functions and often increases with malignancy. Irregular nuclei are linked to aggressive tumors, driven by genetic and epigenetic changes. However, the precise mechanisms controlling nuclear size are still not fully understood. In this study, we demonstrated that cancer-associated speckle-type POZ protein (SPOP) mutations enlarged nuclear size by reducing the protein level of...
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