Emerin is an effector of oncogenic KRAS-driven nuclear dynamics in pancreatic cancer.

doi:10.1172/jci.insight.187799

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Article

Emerin is an effector of oncogenic KRAS-driven nuclear dynamics in pancreatic cancer.

JCI insight - 22 Jul 2025

Flores Luis F, Marks David L, Vera Renzo E, Sigafoos Ashley N, Tolosa Ezequiel J, Almada Luciana L, Pease David R, Toruner Merih D, Chang Brian, Tader Brooke R, LaRue-Nolan Kayla C, Carr Ryan M, Graham Rondell P, Hagen Catherine E, Brown Matthew R, Matveyenko Aleksey V, Wilson Katherine L, Dawson David W, Pin Christopher L, Roux Kyle J, Fernandez-Zapico Martin E

Abstract excerpt

For over a century, scientists reported the disruption of normal nuclear shape and size in cancer. These changes have long been used as tools for diagnosis and staging of malignancies. However, to date, the mechanisms underlying these aberrant nuclear phenotypes and their biological significance remain poorly understood. Using a model of pancreatic ductal adenocarcinoma (PDAC), the major histological subtypes of...

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Topics

Pancreatic Neoplasms
Proto-Oncogene Proteins p21(ras)
Humans
Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Animals

Mice

Membrane Proteins

Nuclear Proteins

Cell Line, Tumor

Cell Nucleus

Mutation

Gene Expression Regulation, Neoplastic

Source

Open in PubMed Open full text

Identifiers

PMID: 40493403
DOI: 10.1172/jci.insight.187799
PMCID: PMC12288966

Genes

KRAS
EMD

Provenance

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