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DNA damage repair in megakaryopoiesis: molecular and clinical aspects

9 Aug 2024

Abstract excerpt

INTRODUCTION: Endogenous DNA damage is a significant factor in the damage of hematopoietic cells. Megakaryopoiesis is one of the pathways of hematopoiesis that ends with the production of platelets and plays the most crucial role in hemostasis. Despite the presence of efficient DNA repair mechanisms, some endogenous lesions can lead to mutagenic alterations, disruption of pathways of hematopoiesis including...

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PMID: 39117495
DOI: 10.1080/17474086.2024.2391102

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