Article
A genome-wide association study identifies an African-specific locus on chromosome 21q22.12 associated with Burkitt lymphoma risk and survival.
Leukemia - 1 Sept 2025
Dutta Diptavo, Gouveia Mateus H, Gorman Bryan R, Adu-Gyamfi Atuahene, Lee Chia-Han, Ogwang Martin D, Kerchan Patrick, Reynolds Steven J, Tenge Constance N, Were Pamela A, Wekesa Walter N, Tenge Robert K, Masalu Nestory, Kawira Esther L, Kinyera Tobias, Otim Isaac, Nabalende Hadijah, Dhudha Herry, Candia Bosco, Abaru Janet, Yan Wusheng, Florez-Vargas Oscar, Xie Yi, Ho Michelle, Ayers Leona W, Bhatia Kishor, Goedert James J, Pfeiffer Ruth M, Manning Michelle, Hutchinson Amy, Cole Nathan, Luo Wen, Hicks Belynda, Chagaluka George, Johnston W Thomas, Mutalima Nora, Borgstein Eric, Liomba George N, Kamiza Steven, Mkandawire Nyengo, Molyneux Elizabeth M, Mitambo Collins, Newton Robert, Siebert Reiner, Dean Michael, Yeager Meredith, Chanock Stephen J, Prokunina-Olsson Ludmila, Mbulaiteye Sam M
Abstract excerpt
Burkitt lymphoma (BL) is a B-cell malignancy that disproportionately affects children in sub-Saharan Africa. We performed a genome-wide association study (GWAS) in a combined set of 800 childhood cases and 3865 controls in East Africa, controlling for age, sex, country, population-specific principal components, and a genetic relationship matrix. This analysis identified a BL-protective region within chromosome...
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