Article
Inherited variants at 3q13.33 and 3p24.1 are associated with risk of diffuse large B-cell lymphoma and implicate immune pathways.
Human molecular genetics - 1 Jan 2020
Kleinstern Geffen, Yan Huihuang, Hildebrandt Michelle A T, Vijai Joseph, Berndt Sonja I, Ghesquières Hervé, McKay James, Wang Sophia S, Nieters Alexandra, Ye Yuanqing, Monnereau Alain, Brooks-Wilson Angela R, Lan Qing, Melbye Mads, Jackson Rebecca D, Teras Lauren R, Purdue Mark P, Vajdic Claire M, Vermeulen Roel C H, Giles Graham G, Cocco Pier Luigi, Birmann Brenda M, Kraft Peter, Albanes Demetrius, Zeleniuch-Jacquotte Anne, Crouch Simon, Zhang Yawei, Sarangi Vivekananda, Asmann Yan, Offit Kenneth, Salles Gilles, Wu Xifeng, Smedby Karin E, Skibola Christine F, Slager Susan L, Rothman Nathaniel, Chanock Stephen J, Cerhan James R
Abstract excerpt
We previously identified five single nucleotide polymorphisms (SNPs) at four susceptibility loci for diffuse large B-cell lymphoma (DLBCL) in individuals of European ancestry through a large genome-wide association study (GWAS). To further elucidate genetic susceptibility to DLBCL, we sought to validate two loci at 3q13.33 and 3p24.1 that were suggestive in the original GWAS with additional genotyping. In the...
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