Integrated analysis of single-cell RNA-seq and spatial transcriptomics to identify the lactylation-related protein TUBB2A as a potential biomarker for glioblastoma in cancer cells by machine learning

Abstract excerpt

Background: An increasing number of studies have revealed a link between lactylation and tumor initiation and progression. However, the specific impact of lactylation on inter-patient heterogeneity and recurrence in glioblastoma (GBM) remains to be further elucidated. Methods: We employed functional enrichment algorithms, including AUCell and UCell, to assess lactylation activity in GBM cancer cells....

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