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UBE2D1 promotes glioblastoma proliferation by modulating p21 ubiquitination

17 Jul 2024

Abstract excerpt

Glioblastoma (GBM) cells exhibit aberrant proliferative abilities and resistance to conventional therapies. However, the mechanisms underlying these malignant phenotypes are poorly understood. In this study, we identified ubiquitin-conjugating enzyme E2D1 (UBE2D1) as a crucial stimulator of GBM development. It is highly expressed in GBM and closely associated with poor prognosis in patients with GBM. UBE2D1...

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PMID: 39016669
DOI: 10.1002/mc.23786

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