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Article

Head and neck tumor organoid grown under simplified media conditions model tumor biology and chemoradiation responses.

Scientific reports - 7 Jul 2025

Li Weilin, Nishino Michiya, Reed Eric, Akshinthala Dipikaa, Pasha Hamdan Ahmed, Anderson Erik S, Huang Ling, Hebestreit Hannah, Monti Stefano, Gomez Ernest D, Jalisi Scharukh M, Muthuswamy Senthil K

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is a prevalent and often fatal malignancy associated with significant treatment-related toxicity. There is an urgent need for a preclinical model to assess therapeutic options and guide clinical decision-making. To define conditions for establishing patient-derived organoid (PDO) models that faithfully recapitulate morphological, histopathological, and genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40624315
DOI: 10.1038/s41598-025-88082-5
PMCID: PMC12234821

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