Article
Detection of cellular senescence within human invasive breast carcinomas distinguishes different breast tumor subtypes.
Oncotarget - 15 Nov 2016
Cotarelo Cristina L, Schad Arno, Kirkpatrick Charles James, Sleeman Jonathan P, Springer Erik, Schmidt Marcus, Thaler Sonja
Abstract excerpt
Oncogene-induced senescence is thought to act as a barrier to tumorigenesis by arresting cells at risk of malignant transformation. Nevertheless, numerous findings suggest that senescent cells may conversely promote tumor progression through the development of the senescence-associated secretome they produce. It is likely that the composition and the physiological consequences mediated by the senescence secretome...
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