Article
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function.
Molecular cell - 17 Jul 2025
Bremer Anne, Lang Walter H, Kempen Ryan P, Sweta Kumari, Taylor Aaron B, Borgia Madeleine B, Ansari Aseem Z, Mittag Tanja
Abstract excerpt
Phase separation regulates many biological processes, but the role of transcription factor (TF)-mediated condensates in gene regulation is contentious. We used Gcn4, a prototypical budding yeast TF, to assess two competing models for transcription activation, i.e., mediated via soluble complexes or through transcriptional condensates. We find that the ability of Gcn4 to form soluble complexes with coactivator...
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