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"Select and Resequence" Methods Enable a Genome-Wide Association Study of the Dimorphic Human Fungal Pathogen Coccidioides posadasii.

Genome biology and evolution - 3 Jul 2025

Voorhies Mark, Joehnk Bastian, Uehling Jessie, Walcott Keith, Dubin Claire A, Mead Heather L, Homer Christina M, Galgiani John N, Barker Bridget M, Brem Rachel B, Sil Anita

Abstract excerpt

Next-generation sequencing has unlocked a wealth of genotype information for wild populations, but interpreting it in the context of phenotypes remains a bottleneck, particularly for nonmodel organisms that are difficult to manipulate. To meet this challenge, we pioneered a method for the mapping of genotype to phenotype in natural populations for the thermally dimorphic pathogenic fungus Coccidioides posadasii,...

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PMID: 40611625
DOI: 10.1093/gbe/evaf135
PMCID: PMC12301965

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