Article

Inferring the composition of a mixed culture of natural microbial isolates by deep sequencing

2024-08-05

Abstract excerpt

Next generation sequencing has unlocked a wealth of genotype information for microbial populations, but phenotyping remains a bottleneck for exploiting this information, particularly for pathogens that are difficult to manipulate. Here, we establish a method for high-throughput phenotyping of mixed cultures, in which the pattern of naturally occurring single-nucleotide polymorphisms in each isolate is used as intr...

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Literature Corpus work: 5e988435-223e-5beb-857c-ddadc54e13e6
DOI: 10.1101/2024.08.05.606565

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