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Barcoded reciprocal hemizygosity analysis via sequencing illuminates the complex genetic basis of yeast thermotolerance.

G3 (Bethesda, Md.) - 4 Feb 2022

Abrams Melanie B, Chuong Julie N, AlZaben Faisal, Dubin Claire A, Skerker Jeffrey M, Brem Rachel B

Abstract excerpt

Decades of successes in statistical genetics have revealed the molecular underpinnings of traits as they vary across individuals of a given species. But standard methods in the field cannot be applied to divergences between reproductively isolated taxa. Genome-wide reciprocal hemizygosity mapping (RH-seq), a mutagenesis screen in an interspecies hybrid background, holds promise as a method to accelerate the...

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PMID: 34878132
DOI: 10.1093/g3journal/jkab412
PMCID: PMC9210320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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