Article
MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury.
JCI insight - 8 Aug 2025
Pickering Harry, Alipanah-Lechner Narges, Chen Ernie, Duchen Dylan, Maecker Holden T, Kim-Schulze Seunghee, Montgomery Ruth R, Cotsapas Chris, Steen Hanno, Krammer Florian, Langelier Charles R, Levy Ofer, Baden Lindsey R, Melamed Esther, Ehrlich Lauren Ir, McComsey Grace A, Sekaly Rafick P, Cairns Charles B, Haddad Elias K, Shaw Albert C, Hafler David A, Corry David B, Kheradmand Farrah, Atkinson Mark A, Brakenridge Scott C, Higuita Nelson I Agudelo, Metcalf Jordan P, Hough Catherine L, Messer William B, Pulendran Bali, Nadeau Kari C, Davis Mark M, Sesma Ana Fernandez, Simon Viviana, Kraft Monica, Bime Chris, Erle David J, Schaenmann Joanna, Ozonoff Al, Peters Bjoern, Kleinstein Steven H, Augustine Alison D, Diray-Arce Joann, Becker Patrice M, Rouphael Nadine, Altman Matthew C, Bosinger Steve, Eckalbar Walter, Calfee Carolyn S, Aguilar Oscar A, Reed Elaine F, Greenland John R, Calabrese Daniel R
Abstract excerpt
MHC class I polypeptide-related sequence B (MICB) is a ligand for NKG2D. We have shown NK cells are central to lung transplant acute lung injury (ALI) via NKG2D activation, and increased MICB in bronchoalveolar lavage predicts ALI severity. Separately, we found a MICB polymorphism (MICBG406A) is associated with decreased ALI risk. We hypothesized this polymorphism would protect against severe SARS-CoV-2...
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