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The HLA-B -21 M/T dimorphism associates with disease severity in COVID-19.

Genes and immunity - 1 Feb 2025

Strunz Benedikt, Momayyezi Pouria, Bilev Eleni, Muvva Jagadeeswara Rao, Chen Puran, Bister Jonna, Schaffer Marie, Akber Mira, Cornillet Martin, Horowitz Amir, Malmberg Karl-Johan, Rooyackers Olav, Aleman Soo, Ljunggren Hans-Gustaf, Björkström Niklas K, Strålin Kristoffer, Hammer Quirin

Abstract excerpt

Host genetics shape immune responses and influence severity of infectious diseases. The HLA-B -21 M/T dimorphism tunes the functionality of natural killer (NK) cells expressing the inhibitory receptor NKG2A. NKG2A+ NK cells have been reported to recognize SARS-CoV-2-infected cells, but it remains unclear whether the HLA-B -21 M/T dimorphism associates with COVID-19 severity. Here, we investigated the influence of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39487235
DOI: 10.1038/s41435-024-00302-6
PMCID: PMC11832411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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