Article
The HLA-B -21 M/T dimorphism associates with disease severity in COVID-19.
Genes and immunity - 1 Feb 2025
Strunz Benedikt, Momayyezi Pouria, Bilev Eleni, Muvva Jagadeeswara Rao, Chen Puran, Bister Jonna, Schaffer Marie, Akber Mira, Cornillet Martin, Horowitz Amir, Malmberg Karl-Johan, Rooyackers Olav, Aleman Soo, Ljunggren Hans-Gustaf, Björkström Niklas K, Strålin Kristoffer, Hammer Quirin
Abstract excerpt
Host genetics shape immune responses and influence severity of infectious diseases. The HLA-B -21 M/T dimorphism tunes the functionality of natural killer (NK) cells expressing the inhibitory receptor NKG2A. NKG2A+ NK cells have been reported to recognize SARS-CoV-2-infected cells, but it remains unclear whether the HLA-B -21 M/T dimorphism associates with COVID-19 severity. Here, we investigated the influence of...
Topics
- Humans
- COVID-19
- Female
- Male
- Middle Aged
- Severity of Illness Index
- SARS-CoV-2
- Aged
- Killer Cells, Natural
- HLA-B Antigens