Identification of candidate genes associated with bipolar disorder by whole-exome sequencing of a Chinese multi-affected pedigree.

Abstract excerpt

BACKGROUND: Bipolar disorder (BD) is a severe mental disorder with high, approximately 70% heritability. Here, to identify novel risk genes of BD, we conducted whole-exome sequencing and pathway enrichment analyses across one multi-affected, southern Chinese Han pedigree. METHODS: Whole-exome sequencing (WES) was performed on five patients with BD and three unaffected members in one multi-affected pedigree. The...

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