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Article

RELN biallelic variant as a candidate risk factor in a consanguineous Pakistani family with bipolar disorder and clinical heterogeneity.

Journal of affective disorders - 15 Jul 2026

Hashmi Aisha Nasir, Harripaul Ricardo S, Muhammad Tahir, Lowther Benjamin J, Mikhailov Anna, Agha Zehra, Qamar Raheel, Vincent John B, Azam Maleeha

Abstract excerpt

BACKGROUND: Bipolar disorder (BD) is highly heritable, polygenic, multifactorial, and has complex genetic heterogeneity. This study aimed to identify rare variants contributing to the aetiology of BD in a consanguineous family from Pakistan. METHODS: Genome-wide SNP microarray and whole exome sequencing (WES) were used for variant identification in a large BD-affected consanguineous Pakistani family. RESULTS: In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41785923
DOI: 10.1016/j.jad.2026.121554

Genes

RELN
HBD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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