Impact of body weight on mycophenolic acid population pharmacokinetics in paediatric lupus nephritis: a pharmacogenomic integration study.

doi:10.1136/lupus-2025-001535

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Article

Impact of body weight on mycophenolic acid population pharmacokinetics in paediatric lupus nephritis: a pharmacogenomic integration study.

Lupus science & medicine - 1 Jul 2025

Ye Chen, Liu Baojing, Chen Lizhi, Zhang Lu, Zheng Yifan, Tang Kejing, Jiang Xiaoyun, Chen Pan

Abstract excerpt

BACKGROUND: Mycophenolic acid (MPA) is recommended for the treatment of lupus nephritis (LN). However, the high pharmacokinetic (PK) variability of MPA contributes to its suboptimal efficacy and an increased incidence of adverse reactions. Rare data reported the impacts of genetic and clinical characteristics on MPA clearance in the paediatric patients with LN. METHODS: Paediatric patients with LN receiving...

Read the complete abstract on PubMed

Topics

Humans
Mycophenolic Acid
Lupus Nephritis
Child
Female
Male
Adolescent

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Body Weight

Multidrug Resistance-Associated Protein 2

Prospective Studies

Immunosuppressive Agents

Area Under Curve

Pharmacogenetics

Polymorphism, Single Nucleotide

UDP-Glucuronosyltransferase 1A9

Child, Preschool

ATP-Binding Cassette, Sub-Family C Proteins

Glucuronosyltransferase

Source

Open in PubMed Open full text

Identifiers

PMID: 40592714
DOI: 10.1136/lupus-2025-001535
PMCID: PMC12215139

Genes

ABCC2
CES1
UGT1A9

Provenance

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