Article
An integrated sampling strategy for therapeutic mycophenolic acid monitoring in lung transplant recipients.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Jan 2025
Tague Laneshia K, Anthony Hephzibah, Salama Noha N, Hachem Ramsey R, Gage Brian F, Gelman Andrew E
Abstract excerpt
BACKGROUND: Mycophenolic Acid (MPA) is the most used anti-proliferative in lung transplantation, but its pharmacokinetic (PK) variability has precluded therapeutic drug monitoring. Both genetic and clinical factors have been implicated in MPA variability. This study aimed to integrate genetic and clinical factors with PK measurements to quantify MPA exposure. METHODS: We performed 12-hour pharmacokinetic analysis...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.