Development and validation of next-generation sequencing-based clinical test for triazole resistance prediction in Aspergillus fumigatus.

Abstract excerpt

The rising rates of triazole drug resistance in Aspergillus fumigatus have placed greater reliance on antifungal susceptibility testing (AFST) to guide therapeutic management, particularly in medically complicated patients. Current methods, however, utilize conventional phenotypic assays that may pose significant challenges in performance, result interpretation, and time to reporting. Herein, we developed and...

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