Article
High-frequency triazole resistance found In nonculturable Aspergillus fumigatus from lungs of patients with chronic fungal disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 May 2011
Denning David W, Park Steven, Lass-Florl Cornelia, Fraczek Marcin G, Kirwan Marie, Gore Robin, Smith Jaclyn, Bueid Ahmed, Moore Caroline B, Bowyer Paul, Perlin David S
Abstract excerpt
BACKGROUND: Oral triazole therapy is well established for the treatment of invasive (IPA), allergic (ABPA), and chronic pulmonary (CPA) aspergillosis, and is often long-term. Triazole resistance rates are rising internationally. Microbiological diagnosis of aspergillosis is limited by poor culture yield, leading to uncertainty about the frequency of triazole resistance. METHODS: Using an ultrasensitive real-time...
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