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Transforming Growth Factor‐β Pathway: Biological Functions and Therapeutic Targets

27 Jun 2025

Abstract excerpt

Cancer progression is often driven by aberrant cell growth and genetic mutations, leading to metastasis. The transforming growth factor-beta (TGF-β) pathway, a key regulator of cellular growth and differentiation, exhibits dual roles in cancer by initially acting as a tumor suppressor and later promoting tumor progression and metastasis. Natural compounds, recognized for their diverse bioactivities and low...

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PMID: 40584407
DOI: 10.1002/mco2.70278

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