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Article

Relevance of Fusion Genes in Pediatric Cancers: Toward Precision Medicine

9 Feb 2017

Abstract excerpt

Pediatric cancers differ from adult tumors, especially by their very low mutational rate. Therefore, their etiology could be explained in part by other oncogenic mechanisms such as chromosomal rearrangements, supporting the possible implication of fusion genes in the development of pediatric cancers. Fusion genes result from chromosomal rearrangements leading to the juxtaposition of two genes. Consequently, an...

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Identifiers

PMID: 28325298
DOI: 10.1016/j.omtn.2017.01.005

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