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Article

Contribution of Polygenic Scores to Progression Independent of Relapse Activity in Multiple Sclerosis.

European journal of neurology - 1 Jul 2025

Clarelli Ferdinando, Sorosina Melissa, Giordano Antonino, Mascia Elisabetta, Visentin Giulia, Missaglia Matteo, Moiola Lucia, Rocca Maria A, Filippi Massimo, Esposito Federica

Abstract excerpt

BACKGROUND: Despite effective therapeutic control of relapses, many patients with multiple sclerosis (MS) experience, from the earliest phases of disease, disability accrual, which mostly occurs as progression independent of relapse activity (PIRA). In this observational study, we aimed at evaluating the genetic contribution to PIRA, using polygenic risk scores (PRS) in a cohort of 1162 Italian patients. METHODS:...

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PMID: 40583592
DOI: 10.1111/ene.70264
PMCID: PMC12207093

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