Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extension of replicative lifespan by synthetic engineered telomerase RNA in patient induced pluripotent stem cells.

Nature biomedical engineering - 1 Dec 2025

Nagpal Neha, Agarwal Suneet

Abstract excerpt

RNA engineering has yielded a new class of medicines but faces limitations depending on RNA size and function. Here we demonstrate the synthesis and enzymatic stabilization of telomerase RNA component (TERC), a therapeutically relevant long non-coding RNA (lncRNA) that extends telomere length and replicative lifespan in human stem cells. Compared with therapeutic mRNAs, engineered TERC RNA (eTERC) depends on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HEK293 Cells
Share to Induced Pluripotent Stem Cells
Share to Longevity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA, Long Noncoding

Share to RNA Stability

Share to Telomerase

Share to Telomere Homeostasis

Source

Open in PubMed Open full text

Identifiers

PMID: 40579489
DOI: 10.1038/s41551-025-01429-1
PMCID: PMC12699389

Genes

CD34
TENT4B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extension of replicative lifespan by synthetic engineered telomerase RNA in patient induced pluripotent stem cells.PMID 40579489Read ↗

Canonical and non-canonical functions of the non-coding RNA component (TERC) of telomerase complexSemantic proximity Read ↗

Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cellsSemantic proximity Read ↗

Telomerase RNA processing: Implications for human health and diseaseSemantic proximity Read ↗

Telomerase as a Cancer Target. Development of New MoleculesSemantic proximity Read ↗

Saturating variant analysis of TERC redefines the human telomerase reverse transcription mechanismSemantic proximity Read ↗

Recent Patents on Anti-Telomerase Cancer TherapySemantic proximity Read ↗

Oligonucleotides and microRNAs Targeting Telomerase Subunits in Cancer TherapySemantic proximity Read ↗

Posttranscriptional manipulation of TERC reverses molecular hallmarks of telomere disease.Semantic proximity Read ↗

Telomerase dynamics in stem cells: Unraveling the molecular nexus of cellular aging and regenerationSemantic proximity Read ↗

Exosome-mediated decay of unstable long extended precursors of human telomerase RNA is dependent on 5'-cap trimethylation.Semantic proximity Read ↗

The RNA Component of Human TelomeraseSemantic proximity Read ↗

Telomerase inhibitors and ‘T-oligo’ as cancer therapeutics: contrasting molecular mechanisms of cytotoxicitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.