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Recent Patents on Anti-Telomerase Cancer Therapy

3 Dec 2011

Abstract excerpt

Telomerase, a specialised RNA-directed DNA polymerase extends and stabilises the telomeres at the ends of the eukaryotic chromosomes. The progressive loss of telomeres results in limited number of cell divisions and has been linked to the mechanism of human cellular ageing. Tumour cells marked by indefinite proliferation have stable telomere length maintained by telomerase. The differential expression of the...

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PMID: 21854360
DOI: 10.2174/157489212798357958

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