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Gene of the month: TMPRSS2 (transmembrane serine protease 2)

1 Sept 2020

Abstract excerpt

Transmembrane serine protease 2 is encoded by the TMPRSS2 gene. The gene is widely conserved and has two isoforms, both being autocatalytically activated from the inactive zymogen form. A fusion gene between the TMPRSS2 gene and ERG (erythroblast-specific-related gene), an oncogenic transcription factor, is the most common chromosomal aberration detected in prostate cancer, responsible for driving carcinogenesis....

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PMID: 32873700
DOI: 10.1136/jclinpath-2020-206987

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