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Article

Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2.

Journal of medical virology - 1 Jul 2021

Abbasi Asim Z, Kiyani Dania A, Hamid Syeda M, Saalim Muhammad, Fahim Ammad, Jalal Nasir

Abstract excerpt

Epidemiological data shows a discrepancy in COVID-19 susceptibility and outcomes with some regions being more heavily affected than others. However, the factors that determine host susceptibility and pathogenicity remain elusive. An increasing number of publications highlight the role of Transmembrane Serine Protease 2 (TMPRSS2) in the susceptibility of the host cell to SARS-CoV-2. Cleavage of viral spike protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33638460
DOI: 10.1002/jmv.26911
PMCID: PMC8014076

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