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Article

Oxidative DNA Damage and Repair Dynamics in Multiple Sclerosis: Insights from Comet Assay Kinetics, Base Excision Repair Gene Expression, and Genotype Analysis.

Biomolecules - 24 May 2025

Filipek Beata, Macieja Anna, Binda Aleksandra, Szelenberger Rafal, Gorniak Leslaw, Miller Elzbieta, Swiderek-Matysiak Mariola, Stasiolek Mariusz, Majsterek Ireneusz, Poplawski Tomasz

Abstract excerpt

Multiple sclerosis (MS) is a neuroinflammatory disease where oxidative stress and DNA damage may influence disease progression. We investigated whether defects in base excision repair (BER) pathways contribute to MS by combining functional DNA repair assays, gene expression profiling, and genotype analysis. We collected peripheral blood mononuclear cells from 70 MS patients and 61 healthy controls. These cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40563398
DOI: 10.3390/biom15060756
PMCID: PMC12190874

Genes

CD4
MBD4
NTHL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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