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Article

Evaluation of potential of targeted sequencing through mutational signature simulation.

PloS one - 1 Jan 2025

Kodama Keisuke, Ling Yiwei, Ichikawa Hiroshi, Wakai Toshifumi, Okuda Shujiro

Abstract excerpt

BACKGROUND: Targeted sequencing is critical in cancer diagnosis, treatment selection, and monitoring. However, the effectiveness of these methods for reflecting whole-exome sequencing (WES)-level mutational signatures remains unclear. Therefore, we addressed this issue through simulation-based analysis to clarify how well targeted sequencing can reproduce WES-level mutational signatures. METHODS: We compared the...

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Topics

Humans
Mutation
Neoplasms
Exome Sequencing
Computer Simulation
Exome
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA Mutational Analysis

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Identifiers

PMID: 40561160
DOI: 10.1371/journal.pone.0326071
PMCID: PMC12193913

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