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Article

SNX8 enables lysosome reformation and reverses lysosomal storage disorder.

Nature communications - 22 Mar 2024

Li Xinran, Xiang Cong, Zhu Shilei, Guo Jiansheng, Liu Chang, Wang Ailian, Cao Jin, Lu Yan, Neculai Dante, Xu Pinglong, Feng Xin-Hua

Abstract excerpt

Lysosomal Storage Disorders (LSDs), which share common phenotypes, including enlarged lysosomes and defective lysosomal storage, are caused by mutations in lysosome-related genes. Although gene therapies and enzyme replacement therapies have been explored, there are currently no effective routine therapies against LSDs. During lysosome reformation, which occurs when the functional lysosome pool is reduced,...

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PMID: 38519472
DOI: 10.1038/s41467-024-46705-x
PMCID: PMC10959956

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