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Strain Engineering and Pathway Enhancement of Bacillus subtilis for Efficient Hyaluronic Acid Production

2025-10-30

Abstract excerpt

<title>Abstract</title> <p> Hyaluronic acid (HA) is a biopolymer with broad biomedical and pharmaceutical uses, yet microbial HA production is limited by strain safety, and process inefficiencies; to address these challenges we engineered a biosafe <italic>Bacillus subtilis</italic> chassis by integrating catalytic genes identified from the BRENDA database. Two constructs on the pHT01 shuttle vector were prepa...

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Literature Corpus work: 8f63ec06-d6ce-57ce-8d76-0e5316506649
DOI: 10.21203/rs.3.rs-7842276/v1

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