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Article

sPLA2-IIA modifies progranulin deficiency phenotypes in mouse models.

Molecular neurodegeneration - 17 Jun 2025

Yang Cha, Du Huan, Lee Gwang Bin, Uematsu Masaaki, He Weiguo, Doré Etienne, Yu Weizhi, Sanford Ethan J, Smolka Marcus B, Boilard Eric, Baskin Jeremy M, Hao Ling, Hu Fenghua

Abstract excerpt

BACKGROUND: Haploinsufficiency of the progranulin (PGRN) protein is a leading cause of frontotemporal lobar degeneration (FTLD). Mouse models have been developed to study PGRN functions. However, PGRN deficiency in the commonly used C57BL/6 mouse strain background leads to very mild phenotypes, and pathways regulating PGRN deficiency phenotypes remain to be elucidated. METHODS: We generated PGRN-deficient mice in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40528203
DOI: 10.1186/s13024-025-00863-8
PMCID: PMC12175356

Genes

GRN

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