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Article

Genetically proxied inhibition of kidney function pathways and increased risk of type 2 diabetes in Africans: A Mendelian randomization study.

Science progress - 1 Jan 2025

Diawara Abdoulaye, Traore Mariam, Diabaté Oudou, Kintu Christopher, Saeed Ali Awadallah, Abiola Julianah Ore, Cisse Cheickna, Traore Kassim, Wele Mamadou, Nash Oyekanmi, Doumbia Seydou O, Abbas Talib Yusuf, Shaffer Jeffrey G, Diakité Mahamadou, Fatumo Segun, Soremekun Opeyemi

Abstract excerpt

ObjectiveTo investigate the causal relationship between genetically predicted inhibition of specific kidney function drug targets and the risk of type 2 diabetes (T2D) in African populations using Mendelian randomization (MR).MethodsWe used MR, a genetic proxy approach, and utilized genome-wide association study data from African participants. This assessed the causal relationship between genetically predicted...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40524645
DOI: 10.1177/00368504251338631
PMCID: PMC12174782

Genes

RHEB
VEGFA

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