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A comparison of human skeletal muscle cell maturation in 2D versus 3D culture: A quantitative proteomic study

1 Jun 2025

Abstract excerpt

Compared with 2D monolayers, 3D models more closely mimic native muscle tissue and allow functional measurements. A more complete understanding of how culture conditions and duration affect myotube maturity/function is crucial for validating the transition to 3D systems. Human skeletal muscle cells were cultured as 2D monolayers or within 3D hydrogels for up to 21 days. Quantitative proteomic analysis and...

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PMID: 40515433
DOI: 10.14814/phy2.70420

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