Article
Association between antinuclear antibodies and the HLA class II locus and heterogeneous characteristics of staining patterns: the Nagahama study.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Dec 2014
Terao Chikashi, Ohmura Koichiro, Yamada Ryo, Kawaguchi Takahisa, Shimizu Masakazu, Tabara Yasuharu, Takahashi Meiko, Setoh Kazuya, Nakayama Takeo, Kosugi Shinji, Sekine Akihiro, Matsuda Fumihiko, Mimori Tsuneyo
Abstract excerpt
OBJECTIVE: While antinuclear antibodies (ANAs) are observed in healthy populations as well as in patients with autoimmune diseases such as systemic lupus erythematosus (SLE), the detailed genetic background of ANAs has remained unclear. We undertook this study to identify the genetic determinants of ANAs in the general population in order to elucidate the underlying mechanisms of ANA production and to distinguish...
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