Immune landscape and novel therapeutic targets of epidermal growth factor receptor and anaplastic lymphoma kinase wild type never-smoker lung adenocarcinoma.

doi:10.1016/j.lungcan.2025.108448

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Article

Immune landscape and novel therapeutic targets of epidermal growth factor receptor and anaplastic lymphoma kinase wild type never-smoker lung adenocarcinoma.

Lung cancer (Amsterdam, Netherlands) - 1 Mar 2025

Choi Wonyoung, Lee Wonyeop, Kim Youngwook, Lee Sang-Jin, Lee Geon Kook, Park Seung-Jin, Ju Sinyeong, Kim Seon-Young, Lee Cheolju, Han Ji-Youn

Abstract excerpt

BACKGROUND: Never-smoker lung adenocarcinoma (NSLA) exhibits distinct immunosuppressive profiles and a lower tumor mutation burden compared with lung adenocarcinoma in smokers. These correlate with poor responses to immune checkpoint inhibitors. In this study, we aimed to elucidate the tumor-immune microenvironment of NSLA without epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK)...

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Topics

Humans
Adenocarcinoma of Lung
Lung Neoplasms
Tumor Microenvironment
ErbB Receptors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Anaplastic Lymphoma Kinase

Male

Female

Middle Aged

Non-Smokers

Aged

Biomarkers, Tumor

Mutation

Transcriptome

Lymphocytes, Tumor-Infiltrating

Prognosis

Source

Open in PubMed

Identifiers

PMID: 39970729
DOI: 10.1016/j.lungcan.2025.108448

Genes

ALK
EGFR
CEACAM1
NECTIN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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