Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteogenomic characterization of pulmonary large-cell neuroendocrine carcinoma identifies molecular features and therapeutic strategy.

Science advances - 14 Aug 2026

Zhang Lele, Sun Liangdong, Duan Shengnan, Yan Yilv, Song Jinyi, Xia Linghui, Yu Huansha, Sun Jijun, Hu Junjie, Wang Di, Han Lu, Wang Jue, Chen Yan, Zhou Hu, Wang Chen, Hu Haiyang, Ding Ming, Zhang Peng

Abstract excerpt

Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare yet highly aggressive subtype of non-small cell lung carcinoma (NSCLC) with limited therapeutic options. We conduct a comprehensive proteogenomic analysis of LCNEC using tumors and paired normal adjacent tissues from 107 patients (81 pure LCNEC and 26 combined LCNEC). APOBEC mutational signatures strongly correlate processes of tumor initiation and...

Topics

Join the communities discussing this publication.

Carcinoma, Large Cell
Carcinoma, Neuroendocrine
KEAP1 gene
Lung Neoplasms
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 42585338
DOI: 10.1126/sciadv.adz0583
PMCID: PMC13464647

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteogenomic characterization of pulmonary large-cell neuroendocrine carcinoma identifies molecular features and therapeutic strategy.PMID 42585338Read ↗

Integrated Molecular and Clinical Characterization of Pulmonary Large Cell Neuroendocrine CarcinomaSemantic proximity Read ↗

Integrative multi-omics profiling deciphers tumor microenvironment heterogeneity and immunotherapy vulnerabilities in lung neuroendocrine carcinomas.Semantic proximity Read ↗

Molecular Pathology of Pulmonary Large Cell Neuroendocrine Carcinoma: Novel Concepts and TreatmentsSemantic proximity Read ↗

Proteogenomic Characterization of High-Grade Lung Neuroendocrine Carcinoma Deciphers Molecular Diversity and Potential Biomarkers of Different Histological Subtypes in Chinese PopulationSemantic proximity Read ↗

Beyond Traditional Morphological Characterization of Lung Neuroendocrine Neoplasms: In Silico Study of Next-Generation Sequencing Mutations Analysis across the Four World Health Organization Defined GroupsSemantic proximity Read ↗

Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets.Semantic proximity Read ↗

Single-cell analysis reveals transcriptomic features and therapeutic targets in primary pulmonary lymphoepithelioma-like carcinomaSemantic proximity Read ↗

YAP1 Status Defines Two Intrinsic Subtypes of LCNEC with Distinct Molecular Features and Therapeutic Vulnerabilities.Semantic proximity Read ↗

The genomic mutational landscape and its correlation with TMB, PD-L1 expression and CD8+ T cell infiltration in Chinese lung large cell neuroendocrine carcinoma.Semantic proximity Read ↗

Real-World comprehensive genomic profiling data for diagnostic clarity in pulmonary Large-Cell neuroendocrine carcinomaSemantic proximity Read ↗

Distinct Molecular Landscape of Epstein–Barr Virus Associated Pulmonary Lymphoepithelioma-Like Carcinoma Revealed by Genomic SequencingSemantic proximity Read ↗

Proteogenomic characterization identifies clinical subgroups in EGFR and ALK wild-type never-smoker lung adenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.