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Article

Genomic and clinical characterization of pediatric lymphoepithelioma-like carcinoma.

Journal of translational medicine - 4 Dec 2024

Que Yi, Lu Xiuxia, Lu Suying, Sun Feifei, Zhu Jia, Zhang Yu, Wang Juan, Huang Junting, Liu Wei, Wang Fenghua, Li Liping, Zhang Li, Gao Min, Zhen Zijun, Zhang Yizhuo

Abstract excerpt

BACKGROUND: Pediatric lymphoepithelioma-like carcinoma (pLELC) is a rare neoplasm with unclear prognosis, genome, and tumor microenvironment. Our study aims to elucidate its genomic and clinical characteristics. METHODS: Forty-one pLELC patients were enrolled at Sun Yat-sen University Cancer Center from 2012 to 2023. Kaplan-Meier analysis was utilized to estimate progression-free survival (PFS) and overall...

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PMID: 39633439
DOI: 10.1186/s12967-024-05921-1
PMCID: PMC11616302

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